Relation Results

Summary

Name RNF208
Full Name RING finger protein 208
Synonyms RN208_HUMAN |
Primary ID Q9H0X6
Links - -
Type protein
Relations 3
Function

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Type: Score: Layout: SPV 
0.20.20.2RNF208VIMUb:E2ESRRA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ RNF208down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination VIM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269051 Lys97 DAINTEFkNTRTNEK Homo sapiens MDA-MB-231 Cell
pmid sentence
Here, we show that RING finger protein 208 (RNF208) decreases the stability of soluble Vimentin protein through a polyubiquitin-mediated proteasomal degradation pathway, thereby suppressing metastasis of TNBC cells
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF208 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271013 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ ESRRAup-regulates quantity by expression img/direct-activation.png transcriptional regulation RNF208 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269052 Homo sapiens MCF-7 Cell
pmid sentence
Furthermore, RNF208 was induced by 17β-estradiol (E2) treatment in an estrogen receptor alpha (ΕRα)-dependent manner
Publications: 1 Organism: Homo Sapiens
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