+ |
CDK1 | down-regulates activity
phosphorylation
|
NUCKS1 |
0.489 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261959 |
Ser181 |
LKATVTPsPVKGKGK |
in vitro |
|
pmid |
sentence |
12413487 |
putative phosphorylation site for Cdk1 is present in the DNA-binding domain peptide. This site, corresponding to Ser 181 in the NUCKS primary structure, is phosphorylated in vitro by Cdk1 with a Km of approximately 35 μM [7]. Phosphorylation of Ser 181 in the synthetic, DNA-binding domain peptide reduces its affinity for DNA-by 100%. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
NUCKS1 | up-regulates
|
DNA_repair |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261960 |
|
|
Homo sapiens |
|
pmid |
sentence |
26323318 |
From these results, we can conclude that NUCKS1 plays a role in HR DNA repair, as does its paralog RAD51AP1. we have tested and uncovered a role for NUCKS1 in HR and in maintaining DNA replication integrity and genome stability. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |