Summary

Name ASCC2
Full Name Activating signal cointegrator 1 complex subunit 2
Synonyms ASC-1 complex subunit p100, Trip4 complex subunit p100 | ASC1P100, RQT3
Primary ID Q9H1I8
Links - -
Type protein
Relations 1
Function Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016). As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes (By similarity). {ECO:0000250|UniProtKB:P53137, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016}.

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Relations

Regulator Mechanism target score ℹ
+ SMURF1 img/unknown.png ubiquitination ASCC2 0.2
Publications: 1 Organism: In Vitro