| + |
AURKB | down-regulates 
phosphorylation
|
DSN1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165546 |
Ser100 |
RQSWRRAsMKETNRR |
Homo sapiens |
|
| pmid |
sentence |
| 20471944 |
To determine whether the combinatorial regulation of the kmn network by aurora b observed in vitro is critical to controlling kinetochore-microtubule attachments in vivo, we next investigated the effect of the phosphomimetic (to aspartate) and nonphosphorylatable (to alanine) mutants of dsn1, knl1, and ndc80 in vertebrate cells. We predicted that both types of mutations in critical phosphorylation sites would affect chromosome segregation, since preventing the inactivation of inappropriately attached kinetochores by aurora b (in the nonphosphorylatable mutant) or constitutively inactivating this attachment (in the phosphomimetic mutant). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165550 |
Ser109 |
KETNRRKsLHPIHQG |
Homo sapiens |
|
| pmid |
sentence |
| 20471944 |
To determine whether the combinatorial regulation of the kmn network by aurora b observed in vitro is critical to controlling kinetochore-microtubule attachments in vivo, we next investigated the effect of the phosphomimetic (to aspartate) and nonphosphorylatable (to alanine) mutants of dsn1, knl1, and ndc80 in vertebrate cells. We predicted that both types of mutations in critical phosphorylation sites would affect chromosome segregation, since preventing the inactivation of inappropriately attached kinetochores by aurora b (in the nonphosphorylatable mutant) or constitutively inactivating this attachment (in the phosphomimetic mutant). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DSN1 | form complex 
binding
|
MIS12 complex |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265189 |
|
|
in vitro |
|
| pmid |
sentence |
| 27881301 |
Human MIS12C (also known as MIND complex or Mtw1 complex in Saccharomyces cerevisiae) contains the MIS12, PMF1, NSL1, and DSN1 subunits |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
DSN1
- 
- 