Summary

Name AURKB
Full Name Aurora kinase B
Synonyms Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B | AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Primary ID Q96GD4
Links - -
Type protein
Relations 121
Inhibitors 2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide; 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea; CCT129202; SNS-314 Mesylate; N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide; ENMD-2076; 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide; AT9283; hesperadin; ZM447439; PF-03814735; CCT137690; CYC-116; TAK-901; N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide; PHA-680632; AMG 900
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation DSN1 0.64
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HASPIN 0.2
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation H3-3A 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.72
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DES 0.526
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CDCA5 0.614
Publications: 6 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.449
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation MYBBP1A 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53BP1 0.421
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NSUN2 0.709
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATM 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RACGAP1 0.772
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPRD1B 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation NDC80 0.842
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SKA3 0.466
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPRE3 0.485
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation YY1 0.377
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.708
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NINL 0.255
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SSU72 0.257
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation SSU72 0.257
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation DIAPH2 0.293
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHMP4C 0.483
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC9 0.266
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KNL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZWINT 0.637
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation H1-4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC5 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AURKB 0.367
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.253
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDCA2 0.459
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CKAP2 0.3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHCBP1 0.38
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CENPA 0.815
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation VIM 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KIF20A 0.772
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation INCENP 0.973
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KIF2C 0.72
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ARHGEF2 0.253
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BIRC5 0.786
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AURKB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLEKHG6 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF4A 0.533
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding AURKB 0.733
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AURKB 0.699
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SKA1 0.725
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png polyubiquitination AURKB 0.436
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding AURKB 0.497
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AURKB 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CPC 0.857
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination AURKB 0.295
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AURKB 0.329
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AURKB 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AURKB 0.973
Publications: 1 Organism: Homo Sapiens