Relation Results

Summary

Name SAV1
Full Name Protein salvador homolog 1
Synonyms 45 kDa WW domain protein, hWW45 | WW45
Primary ID Q9H4B6
Links - -
Type protein
Relations 10
Pathways Hippo Signaling, YAP/TAZ regulation
Function Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restrict ...
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Type: Score: Layout: SPV 
0.2830.8930.8290.8290.20.8830.883STK25SAV1STK3/4STK3STK4

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STK25down-regulates activity img/direct_inhibition.png phosphorylation SAV1 0.283
Identifier Residue Sequence Organism Cell Line
SIGNOR-278369 Thr26 GKYVKKEtSPLLRNL Homo sapiens
pmid sentence
STK25 inhibits the ability of SAV1 to counteract STRIPAK.|Using this antibody, we confirmed that SAV1 WT was indeed phosphorylated by STK25 at T26 in human cells (XREF_FIG).
Publications: 1 Organism: Homo Sapiens
+ SAV1up-regulates activity img/direct-activation.png binding STK3/4 0.893
Identifier Residue Sequence Organism Cell Line
SIGNOR-256183 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263661 Homo sapiens HEK-293 Cell
pmid sentence
The human WW45 protein enhances MST1-mediated apoptosis in vivo In this model, hWW45 binds both MST1 and LATS through its coiled-coil domains and WW domains, respectively, and facilitates the phosphorylation of LATS by MST1. This model could explain the enhanced apoptotic efficacy of MST1 with the over-expression of hWW45 and the attenuated MST1-induced apoptosis with the down-regulation of endogenous hWW45.
Publications: 2 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3up-regulates img/direct-activation.png phosphorylation SAV1 0.829
Identifier Residue Sequence Organism Cell Line
SIGNOR-230716 in vitro HEK-293 Cell
pmid sentence
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav
Publications: 1 Organism: In Vitro
Pathways:Hippo Signaling
+ SAV1up-regulates img/direct-activation.png binding STK3 0.829
Identifier Residue Sequence Organism Cell Line
SIGNOR-169829 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates activity img/direct-activation.png phosphorylation SAV1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256184 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK4up-regulates img/direct-activation.png SAV1 0.883
Identifier Residue Sequence Organism Cell Line
SIGNOR-217833 in vitro
pmid sentence
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav
Publications: 1 Organism: In Vitro
Pathways:Hippo Signaling
+ SAV1up-regulates quantity by stabilization img/direct-activation.png binding STK3 0.829
Identifier Residue Sequence Organism Cell Line
SIGNOR-261957 Homo sapiens T-REx 293 Cell
pmid sentence
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ SAV1up-regulates quantity by stabilization img/direct-activation.png binding STK4 0.883
Identifier Residue Sequence Organism Cell Line
SIGNOR-261958 Homo sapiens
pmid sentence
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ SAV1up-regulates img/direct-activation.png binding STK4 0.883
Identifier Residue Sequence Organism Cell Line
SIGNOR-169832 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
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