Relation Results

Summary

Name SAV1
Full Name Protein salvador homolog 1
Synonyms 45 kDa WW domain protein, hWW45 | WW45
Primary ID Q9H4B6
Links - -
Type protein
Relations 10
Pathways Hippo Signaling, YAP/TAZ regulation
Function Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restrict ...
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Type: Score: Layout: SPV 
0.2810.8860.8340.8860.8950.8340.2STK25SAV1STK4STK3STK3/4

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STK25down-regulates activity img/direct_inhibition.png phosphorylation SAV1 0.281
Identifier Residue Sequence Organism Cell Line
SIGNOR-278369 Thr26 GKYVKKEtSPLLRNL Homo sapiens
pmid sentence
STK25 inhibits the ability of SAV1 to counteract STRIPAK.|Using this antibody, we confirmed that SAV1 WT was indeed phosphorylated by STK25 at T26 in human cells (XREF_FIG).
Publications: 1 Organism: Homo Sapiens
+ STK4up-regulates img/direct-activation.png SAV1 0.886
Identifier Residue Sequence Organism Cell Line
SIGNOR-217833 in vitro
pmid sentence
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav
Publications: 1 Organism: In Vitro
Pathways:Hippo Signaling
+ SAV1up-regulates quantity by stabilization img/direct-activation.png binding STK3 0.834
Identifier Residue Sequence Organism Cell Line
SIGNOR-261957 Homo sapiens T-REx 293 Cell
pmid sentence
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ SAV1up-regulates quantity by stabilization img/direct-activation.png binding STK4 0.886
Identifier Residue Sequence Organism Cell Line
SIGNOR-261958 Homo sapiens
pmid sentence
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ SAV1up-regulates img/direct-activation.png binding STK4 0.886
Identifier Residue Sequence Organism Cell Line
SIGNOR-169832 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ SAV1up-regulates activity img/direct-activation.png binding STK3/4 0.895
Identifier Residue Sequence Organism Cell Line
SIGNOR-263661 Homo sapiens HEK-293 Cell
pmid sentence
The human WW45 protein enhances MST1-mediated apoptosis in vivo In this model, hWW45 binds both MST1 and LATS through its coiled-coil domains and WW domains, respectively, and facilitates the phosphorylation of LATS by MST1. This model could explain the enhanced apoptotic efficacy of MST1 with the over-expression of hWW45 and the attenuated MST1-induced apoptosis with the down-regulation of endogenous hWW45.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256183 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 2 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3up-regulates img/direct-activation.png phosphorylation SAV1 0.834
Identifier Residue Sequence Organism Cell Line
SIGNOR-230716 in vitro HEK-293 Cell
pmid sentence
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav
Publications: 1 Organism: In Vitro
Pathways:Hippo Signaling
+ SAV1up-regulates img/direct-activation.png binding STK3 0.834
Identifier Residue Sequence Organism Cell Line
SIGNOR-169829 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates activity img/direct-activation.png phosphorylation SAV1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256184 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
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