Summary

Name RETREG1
Full Name Reticulophagy regulator 1
Synonyms F134B_HUMAN |
Primary ID Q9H6L5
Links - -
Type protein
Relations 1
Function Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation RETREG1 0.2
Publications: 1 Organism: In Vitro