Summary

Name RNF167
Full Name E3 ubiquitin-protein ligase RNF167
Synonyms RING finger protein 167 | RING105
Primary ID Q9H6Y7
Links - -
Type protein
Relations 6
Function E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:35114100, PubMed:33594058). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ RNF167down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination VAMP3 0.335
Publications: 3 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF167 0.2
Publications: 1 Organism: Homo Sapiens
+ UBE2E1up-regulates activity img/direct-activation.png binding RNF167 0.554
Publications: 1 Organism: Homo Sapiens
+ RNF167down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination SLC22A18 0.541
Publications: 1 Organism: Homo Sapiens