+ |
IKBKB | up-regulates activity
phosphorylation
|
ASB8 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272242 |
Ser31 |
RTIAAIRsFPHDNVE |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
31009856 |
We found that ASB8 was phosphorylated at the N-terminal Ser-31 by host IkappaB kinase beta (IKKbeta). In turn, ASB8 facilitated K48-linked ubiquitination and degradation of IKKbeta via the ubiquitin-proteasome pathway, resulting in remarkable inhibition of I-kappa-B-alpha (IkappaBalpha) and of p65 phosphorylation, consequently suppressing NF-kappaB activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ASB8 | down-regulates quantity by destabilization
ubiquitination
|
IKBKB |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272253 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
31009856 |
In turn, ASB8 facilitated K48-linked ubiquitination and degradation of IKKbeta via the ubiquitin-proteasome pathway, resulting in remarkable inhibition of I-kappa-B-alpha (IkappaBalpha) and of p65 phosphorylation, consequently suppressing NF-kappaB activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |