| Name
|
 PTGES2
|
| Full Name |
Prostaglandin E synthase 2 |
| Synonyms |
Membrane-associated prostaglandin E synthase-2, mPGE synthase-2, Microsomal prostaglandin E synthase 2, mPGES-2, Prostaglandin-H(2) E-isomerase, 5.3.99.3 | C9orf15, PGES2 |
| Primary ID |
Q9H7Z7 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
2 |
| Function |
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity). |
4.0
chemical modification