3.0
Summary
| Name |  ZWILCH
|
| Full Name | Protein zwilch homolog |
| Synonyms | hZwilch | |
| Primary ID | Q9H900 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ZWILCH | form complex 
binding
|
RZZ complex | 0.74 |
| Publications: | 1 | Organism: | Homo Sapiens | |