Relation Results

Summary

Name GP6
Full Name Platelet glycoprotein VI
Synonyms GPVI, Glycoprotein 6 |
Primary ID Q9HCN6
Links - -
Type protein
Relations 5
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thr ...
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Type: Score: Layout: SPV 
0.20.2820.20.2FLI1GP6GATA1SP1ETS1

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Relations
Regulator
Mechanism
target
score ℹ
+ FLI1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254157 Homo sapiens Megakaryocyte Cell Line
pmid sentence
Deletion analyses and site-directed mutagenesis identified Sp1(227), GATA(177), and Ets(48) sites as essential for GPVI expression. We show that transcription factors GATA-1, Fli-1, and Sp1 can bind to and activate this promoter.
Publications: 1 Organism: Homo Sapiens
+ GATA1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP6 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-254081 Homo sapiens
pmid sentence
We have determined that the GP6 sequence -191 to -39 represents the core promoter and that transcription is driven largely by GATA-1 (-176) and c-Ets-1 (-45) sites within this segment.
Identifier Residue Sequence Organism Cell Line
SIGNOR-254158 Homo sapiens
pmid sentence
Deletion analyses and site-directed mutagenesis identified Sp1(227), GATA(177), and Ets(48) sites as essential for GPVI expression. We show that transcription factors GATA-1, Fli-1, and Sp1 can bind to and activate this promoter.
Publications: 2 Organism: Homo Sapiens
+ SP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254159 Homo sapiens Megakaryocyte Cell Line
pmid sentence
Deletion analyses and site-directed mutagenesis identified Sp1(227), GATA(177), and Ets(48) sites as essential for GPVI expression. We show that transcription factors GATA-1, Fli-1, and Sp1 can bind to and activate this promoter.
Publications: 1 Organism: Homo Sapiens
+ ETS1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254082 Homo sapiens
pmid sentence
We have determined that the GP6 sequence -191 to -39 represents the core promoter and that transcription is driven largely by GATA-1 (-176) and c-Ets-1 (-45) sites within this segment.
Publications: 1 Organism: Homo Sapiens
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