3.0
Summary
| Name |  BRMS1View Modifications |
| Full Name | Breast cancer metastasis-suppressor 1 |
| Synonyms | BRMS1_HUMAN | |
| Primary ID | Q9HCU9 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates quantity by destabilization 
phosphorylation
|
BRMS1 | 0.463 |
| Publications: | 1 | Organism: | In Vitro | |
| + | BRMS1 | down-regulates quantity by destabilization
ubiquitination
|
EP300 | 0.37 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRMS1 | up-regulates activity 
binding
|
KDM1A | 0.26 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPOP | down-regulates quantity
ubiquitination
|
BRMS1 | 0.411 |
| Publications: | 1 | Organism: | Homo Sapiens | |