Relation Results

Summary

Name SPAG4
Full Name Sperm-associated antigen 4 protein
Synonyms Outer dense fiber-associated protein SPAG4, SUN domain-containing protein 4 | SUN4
Primary ID Q9NPE6
Links - -
Type protein
Relations 1
Function Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required ...
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Type: Score: Layout: SPV 
0.358SPAG4LINC complex

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+ SPAG4form complex img/form-complex.png binding LINC complex 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-263285
pmid sentence
LINC complex couples the nuclear lamina to the cytoskeleton. SUN domain proteins, SUN1 and SUN2, located at the inner nuclear membrane (INM) interact with the nuclear lamins, Lamin A/C, B1, and B2, that line the nucleoplasmic face of the INM. SUN domain proteins interact with Nesprins in the perinuclear space (PNS). Nesprins protrude from the outer nuclear membrane (ONM) and interact with the cytoskeleton, often through an intermediate binding partner. Nesprin 1 giant (g) and Nesprin 2g potentially link the NE directly to the Z-disc (Z), whereas Nesprin 1alpha and 2alpha may connect via an unknown intermediate protein. In addition, the shorter isoforms of Nesprin 1 and Nesprin 2 may localize to the INM.
Publications: 1
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