4.0
Summary
| Name |  NLRC4View Modifications |
| Full Name | NLR family CARD domain-containing protein 4 |
| Synonyms | CARD, LRR, and NACHT-containing protein, Clan protein, Caspase recruitment domain-containing protein 12, Ice protease-activating factor, Ipaf | CARD12, CLAN, CLAN1, IPAF |
| Primary ID | Q9NPP4 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LRRK2 | up-regulates activity 
phosphorylation
|
NLRC4 | 0.36 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TP53 | up-regulates quantity by expression 
transcriptional regulation
|
NLRC4 | 0.452 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLRC4 | form complex 
binding
|
NLRC4 inflammasome | 0.751 |
| Publications: | 1 | |||