Summary

Name DUOX2
Full Name Dual oxidase 2
Synonyms Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, Thyroid oxidase 2, p138 thyroid oxidase | LNOX2, THOX2
Primary ID Q9NRD8
Links - -
Type protein
Relations 2
Function Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification superoxide 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ROS 0.7
Publications: 1 Organism: Homo Sapiens