| + |
ROS | up-regulates 
|
NFE2L2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267353 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 22789539 |
Nrf2 is a master transcriptional activator of cytoprotective genes. It activates transcription in response to electrophiles and reactive oxygen species (ROS) (Itoh et al., 1997, Uruno and Motohashi, 2011). Under normal conditions, Nrf2 is constantly ubiquitinated by Keap1 and degraded by the proteasome. Exposure to the stimuli inactivates Keap1 and stabilizes Nrf2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
ROS | up-regulates quantity by expression
|
ARNT |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253689 |
|
|
|
|
| pmid |
sentence |
| 22387692 |
Although the regulation mechanism of the ARNT expression is largely unknown, earlier studies reported that the human ARNT protein level was decreased by hydrogen peroxide or reactive oxygen species. |
|
| Publications: |
1 |
| + |
CYBB | up-regulates 
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates quantity
|
SNCA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16000336 |
The increased concentration of neuronal alpha-synuclein and pigment in normal A9 neurons may already predispose these neurons to precipitate alpha-synuclein around pigment-associated lipid under oxidative conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Parkinson |
| + |
superoxide | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35681445 |
The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNAJC14 | down-regulates 
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249698 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15525720 |
Mutations in the gene encoding DJ-1 have also been linked to familial Parkinsons disease. Other studies have suggested that DJ-1 protects cells from oxidative damage, and mutations in DJ-1 may therefore contribute to in- creased levels of oxidative stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Parkinson |
| + |
ROS | up-regulates
transcriptional regulation
|
ATF4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253729 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19439225 |
Oxidative and ER stress conditions induce rapid and significant activation of ATF4 downstream of eIF2alpha phosphorylation, which is responsible for Redd1 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates
|
ATM |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262791 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26344566 |
We report that the PEX5 peroxisome import receptor binds ataxia-telangiectasia mutated (ATM) and localizes this kinase to the peroxisome. In response to ROS, ATM signalling activates ULK1 and inhibits mTORC1 to induce autophagy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF7 | down-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23136067 |
We examined potential role of SAG in conferring cellular radioresistance, based upon two pieces of evidence. First, SAG is an antioxidant protein that scavenges ROS. R |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates activity
|
NLRP3 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256427 |
|
|
|
|
| pmid |
sentence |
| 28531279 |
Different mechanisms have been proposed for NLRP3 activation, including potassium efflux, calcium influx, reactive oxygen species (ROS), oxidized mitochondrial DNA, translocation of cardiolipin from the inner mitochondrial membrane, phagosome destabilization, perturbation in cell volume and pore-formation mechanisms driven by the host or bacteria |
|
| Publications: |
1 |
| + |
TNFRSF21 | down-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263830 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32454942 |
Further, data from our laboratories indicate that selective agonism of TNFR2 rescues neurons from oxidative stress-induced cell death [160] and excitotoxic cell death [161, 162]. Similarly, TNFR2 activation induces expression of antiapoptotic and detoxifying proteins and protects OPCs against oxidative stress. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263831 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32454942 |
Further, data from our laboratories indicate that selective agonism of TNFR2 rescues neurons from oxidative stress-induced cell death [160] and excitotoxic cell death [161, 162]. Similarly, TNFR2 activation induces expression of antiapoptotic and detoxifying proteins and protects OPCs against oxidative stress. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
NOX1 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MPO-ANCA | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270590 |
|
|
in vitro |
|
| pmid |
sentence |
| 2161532 |
ANCA-induced release of ROS measured by chemiluminescence. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NOX4 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264717 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates quantity by expression
transcriptional regulation
|
PAX2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252295 |
|
|
Mus musculus |
Embryonic Kidney Cell Line |
| pmid |
sentence |
| 16985513 |
High glucose-induced Pax-2 gene expression is mediated, at least in part, via ROS generation and activation of the nuclear factor kappa B signaling pathway, but not via protein kinase C, p38 mitogen-activated protein kinase (MAPK), and p44/42 MAPK signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
DUOX1 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates
|
MAP3K5 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11266364 |
TNF- but not Fas-induced apoptosis requires ROS-dependent activation of ASK1_JNK/p38 pathways. Thus, ASK1 is selectively required for TNF- and oxidative stress-induced sustained activations of JNK/p38 and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
ROS | up-regulates
|
GSTA4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264797 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12646569 |
We have also provided evidence that the mitochondrial GSTA4-4 level markedly increases in COS cells under oxidative stress conditions, suggesting its critical role in maintaining the GSH homeostasis under conditions of chemical and oxidative stress |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NOX3 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264715 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogen peroxide | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35681445 |
The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates
|
Demyelination |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32454942 |
Next to their interaction with adaptive immune cells, activated microglia can secrete cytotoxic cytokines and oxidative products, such as ROS and NO radicals in MS lesions thereby promoting oxidative stress and contributing to myelin destruction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
ROS | up-regulates
|
Oxidative_stress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272275 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22301329 |
Oxidative stress is defined by an imbalance between increased levels of reactive oxygen species (ROS) and a low activity of antioxidant mechanisms. An increased oxidative stress can induce damage to the cellular structure and potentially destroy tissues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nitric oxide | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35681445 |
The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
ROS | up-regulates
|
PPARGC1A |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253397 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18074631 |
In fact, experiments with either genetic knockouts or RNAi for the PGC1s show that the ability of ROS to induce a ROS scavenging programme depends entirely on the PGC1s. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DUOX2 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates quantity by expression
transcriptional regulation
|
FOXL2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19010791 |
Transcriptional upregulation of foxl2 during oxidative and heat stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOX5 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264718 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ROS