| Name
|
 SMYD2
|
| Full Name |
N-lysine methyltransferase SMYD2 |
| Synonyms |
HSKM-B, Histone methyltransferase SMYD2, 2.1.1.43, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2 | KMT3C |
| Primary ID |
Q9NRG4 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. |
3.0
methylation