4.0
Summary
| Name |  METTL5
|
| Full Name | rRNA N(6)-adenosine-methyltransferase METTL5 |
| Synonyms | Methyltransferase-like protein 5 | |
| Primary ID | Q9NRN9 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665, PubMed:33357433, PubMed:33428944, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:33357433). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | METTL5 | form complex 
binding
|
METTL5-TRM112 methyltransferase complex | 0.356 |
| Publications: | 1 | Organism: | Homo Sapiens | |