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Summary
Name
PHPT1
View Modifications
Full Name
14 kDa phosphohistidine phosphatase
Synonyms
EC 3.9.1.3, Phosphohistidine phosphatase 1, PHPT1, Protein histidine phosphatase, PHP, Protein janus-A homolog | PHP14
Primary ID
Q9NRX4
Links
-
-
Type
protein
Relations
1
Function
Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}.
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by mechanism
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dephosphorylation
by effect
none
down-regulates activity
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
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Modifications Tables
PHPT1 as Modifier
Residue
Sequence
Target
Effect
Modification
His358
FRQVRLKhRKLREQV
KCNN4
inhibition
dephosphorylation
Relations
Regulator
Mechanism
target
score
ℹ
+
PHPT1
down-regulates activity
dephosphorylation
KCNN4
0.566
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-277071
His358
FRQVRLKhRKLREQV
Homo sapiens
pmid
sentence
18796614
We now show that the mammalian protein histidine phosphatase (PHPT-1) directly binds and inhibits KCa3.1 by dephosphorylating histidine 358 on KCa3.1.|Overexpression of wild-type, but not a phosphatase dead, PHPT-1 inhibited KCa3.1 channel activity.
Publications:
1
Organism:
Homo Sapiens