Summary

Name AGPAT3
Full Name 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
Synonyms 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGP acyltransferase 3, 1-AGPAT 3, Lysophosphatidic acid acyltransferase gamma, LPAAT-gamma | LPAAT3
Primary ID Q9NRZ7
Links - -
Type protein
Relations 2
Function Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification 1-acyl-sn-glycerol 3-phosphate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical modification phosphatidic acid 0.8
Publications: 1 Organism: Homo Sapiens