3.0
Summary
| Name |  TOPORSView Modifications |
| Full Name | E3 ubiquitin-protein ligase Topors |
| Synonyms | SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, p53-binding protein 3, p53BP3 | LUN, TP53BPL |
| Primary ID | Q9NS56 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK1 | up-regulates activity 
phosphorylation
|
TOPORS | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
TOPORS | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TOPORS | down-regulates 
ubiquitination
|
TP53 | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |