Summary

Name ACSS1
Full Name Acetyl-coenzyme A synthetase 2-like, mitochondrial
Synonyms EC 6.2.1.1, Acetate--CoA ligase 2, Acetyl-CoA synthetase 2, AceCS2, Acyl-CoA synthetase short-chain family member 1, Propionate--CoA ligase, EC 6.2.1.17 | ACAS2L, KIAA1846
Primary ID Q9NUB1
Links - -
Type protein
Relations 3
Function Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). {ECO:0000250|UniProtKB:Q99NB1, ECO:0000269|PubMed:16788062}.

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Relations

Regulator Mechanism target score ℹ
+ ACSS1down-regulates quantity img/direct_inhibition.png chemical modification coenzyme A(4-) 0.8
Publications: 1
+ ACSS1up-regulates quantity img/direct-activation.png chemical modification acetyl-CoA(4-) 0.8
Publications: 1
+ ACSS1down-regulates quantity img/direct_inhibition.png chemical modification acetate 0.8
Publications: 1