Summary

Name LIN7C
Full Name Protein lin-7 homolog C
Synonyms Lin-7C, Mammalian lin-seven protein 3, MALS-3, Vertebrate lin-7 homolog 3, Veli-3 | MALS3, VELI3
Primary ID Q9NUP9
Links - -
Type protein
Relations 1
Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Viewer

Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding AMOT/MPP5/INADL/LIN7C 0.14
Publications: 1 Organism: Homo Sapiens