4.0
Summary
| Name |  TDP1View Modifications |
| Full Name | Tyrosyl-DNA phosphodiesterase 1 |
| Synonyms | Tyr-DNA phosphodiesterase 1 |
| Primary ID | Q9NUW8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
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phosphorylation