| + |
FANCL | up-regulates activity 
ubiquitination
|
FANCD2 |
0.899 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263250 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263264 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCD2 and Fanconi anemia core components (broken pink circles) affects the efficiency of, but is not essential for, ID ubiquitination by the FA core complex, together with E1 and UBE2T. Analogously, ubiquitination of FANCD2 (solid orange ovals) is essential for DNA repair, activating the ID complex for chromatin binding |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| + |
FANCL | up-regulates activity
ubiquitination
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22653977 |
Here we provide evidence that FANCL increases the activity and expression of beta-catenin, a key pluripotency factor in hematopoietic stem cells.|We show that FANCL ubiquitinates \u03b2-catenin with atypical ubiquitin chain extension known to have nonproteolytic functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCL | down-regulates quantity 
ubiquitination
|
UBE2T |
0.899 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278809 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16916645 |
Monoubiquitination of UBE2T was enhanced by FANCL introduction, suggesting that FANCL feeds back to UBE2T and can downregulate its activity.Although the FA pathway has been extensively studied, the E2 enzyme cooperating with the FA core complex for monoubiquitination of FANCD2 has not been discovered.|This monoubiquitination is stimulated by the presence of the FANCL protein and inactivates UBE2T. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UBE2T | up-regulates activity
ubiquitination
|
FANCL |
0.899 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263263 |
|
|
in vitro |
|
| pmid |
sentence |
| 24389026 |
Using the Fanconi Anemia pathway exclusive E3-E2 pair, FANCL-Ube2T, we report the atomic structure of the FANCL RING-Ube2T complex|Our structural and biochemical analyses suggest that, in a cellular environment with multiple E2s present, FANCL will preferentially select Ube2T. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
FANCL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCL | form complex 
binding
|
Fanconi anemia core complex |
0.907 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263245 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCL | up-regulates activity
ubiquitination
|
FANCI |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263266 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCD2 and Fanconi anemia core components (broken pink circles) affects the efficiency of, but is not essential for, ID ubiquitination by the FA core complex, together with E1 and UBE2T. Analogously, ubiquitination of FANCD2 (solid orange ovals) is essential for DNA repair, activating the ID complex for chromatin binding |
|
| Publications: |
1 |
3.0
FANCL
- 
- 