| + |
FANCL | up-regulates activity 
ubiquitination
|
FANCI |
0.838 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263266 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCD2 and Fanconi anemia core components (broken pink circles) affects the efficiency of, but is not essential for, ID ubiquitination by the FA core complex, together with E1 and UBE2T. Analogously, ubiquitination of FANCD2 (solid orange ovals) is essential for DNA repair, activating the ID complex for chromatin binding |
|
| Publications: |
1 |
| + |
UBE2T | up-regulates activity
ubiquitination
|
FANCL |
0.897 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263263 |
|
|
in vitro |
|
| pmid |
sentence |
| 24389026 |
Using the Fanconi Anemia pathway exclusive E3-E2 pair, FANCL-Ube2T, we report the atomic structure of the FANCL RING-Ube2T complex|Our structural and biochemical analyses suggest that, in a cellular environment with multiple E2s present, FANCL will preferentially select Ube2T. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FANCL | form complex 
binding
|
Fanconi anemia core complex |
0.906 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263245 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCL | up-regulates activity
ubiquitination
|
FANCD2 |
0.897 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263250 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263264 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCD2 and Fanconi anemia core components (broken pink circles) affects the efficiency of, but is not essential for, ID ubiquitination by the FA core complex, together with E1 and UBE2T. Analogously, ubiquitination of FANCD2 (solid orange ovals) is essential for DNA repair, activating the ID complex for chromatin binding |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
FANCL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FANCL
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