Relation Results

Name	CMTM6
Full Name	CKLF-like MARVEL transmembrane domain-containing protein 6
Synonyms	Chemokine-like factor superfamily member 6 \| CKLFSF6
Primary ID	Q9NX76
Links	- -
Type	protein
Relations	1
Function	Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000269\|PubMed:28813410, ECO:0000269\|PubMed:28813417}.