Relation Results

Summary

Name FBXL12
Full Name F-box/LRR-repeat protein 12
Synonyms F-box and leucine-rich repeat protein 12, F-box protein FBL12 | FBL12
Primary ID Q9NXK8
Links - -
Type protein
Relations 5
Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal ...
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Type: Score: Layout: SPV 
0.3210.3210.480.680.321FBXL12ALDH3A1ALDH3A2CAMK1Cullin 1-RBX1-Skp1ALDH3B1

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Relations
Regulator
Mechanism
target
score ℹ
+ FBXL12down-regulates quantity by destabilization img/direct_inhibition.png binding ALDH3A1 0.321
Identifier Residue Sequence Organism Cell Line
SIGNOR-272813 Mus musculus
pmid sentence
We now show that SCFFBXL12 is an authentic E3 for the ALDH3 family of enzymes. We now show that the ubiquitin-dependent degradation of ALDH3 mediated by FBXL12 (F box and leucine-rich repeat protein 12) is essential for execution of the differentiation program of trophoblast stem cells (TSCs). FBXL12 is present only in eutherian mammals, and its expression is largely restricted to the placenta during mouse embryogenesis. FBXL12 was found to interact specifically with members of the ALDH3 family and to mediate their polyubiquitylation. Finally, coimmunoprecipitation analysis revealed that FBXL12 interacted efficiently only with members of the ALDH3 family (ALDH3A1, ALDH3A2, and ALDH3B1), showing little if any association with those of the ALDH1 family (ALDH1A1, ALDH1A2, and ALDH1A3) (Fig. 2H). Collectively, these results suggested that SCFFBXL12 is an authentic E3 specific for ALDH3 family members.
Publications: 1 Organism: Mus Musculus
Tissue: Placenta
+ FBXL12down-regulates quantity by destabilization img/direct_inhibition.png binding ALDH3A2 0.321
Identifier Residue Sequence Organism Cell Line
SIGNOR-272814 Mus musculus
pmid sentence
We now show that SCFFBXL12 is an authentic E3 for the ALDH3 family of enzymes. We now show that the ubiquitin-dependent degradation of ALDH3 mediated by FBXL12 (F box and leucine-rich repeat protein 12) is essential for execution of the differentiation program of trophoblast stem cells (TSCs). FBXL12 is present only in eutherian mammals, and its expression is largely restricted to the placenta during mouse embryogenesis. FBXL12 was found to interact specifically with members of the ALDH3 family and to mediate their polyubiquitylation. Finally, coimmunoprecipitation analysis revealed that FBXL12 interacted efficiently only with members of the ALDH3 family (ALDH3A1, ALDH3A2, and ALDH3B1), showing little if any association with those of the ALDH1 family (ALDH1A1, ALDH1A2, and ALDH1A3) (Fig. 2H). Collectively, these results suggested that SCFFBXL12 is an authentic E3 specific for ALDH3 family members.
Publications: 1 Organism: Mus Musculus
Tissue: Placenta
+ FBXL12down-regulates quantity img/direct_inhibition.png ubiquitination CAMK1 0.48
Identifier Residue Sequence Organism Cell Line
SIGNOR-261193 Mus musculus MLE-12 Cell
pmid sentence
Here, we show that a ubiquitin E3 ligase component, F-box protein Fbxl12, mediates CaMKI degradation via a proteasome-directed pathway leading to disruption of cyclin D1/cdk4 complex. Endogenous Fbxl12 and CaMKI interacted as demonstrated after Fbxl12 immuno-precipitation followed by immunoblot analysis with CaMKI antibodies assembly and resultantG1 arrest in lung epithelia. Fbxl12 targets CaMKI for ubiquitination.
Publications: 1 Organism: Mus Musculus
+ FBXL12up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.68
Identifier Residue Sequence Organism Cell Line
SIGNOR-272816 Mus musculus
pmid sentence
We now show that SCFFBXL12 is an authentic E3 for the ALDH3 family of enzymes. We now show that the ubiquitin-dependent degradation of ALDH3 mediated by FBXL12 (F box and leucine-rich repeat protein 12) is essential for execution of the differentiation program of trophoblast stem cells (TSCs). FBXL12 is present only in eutherian mammals, and its expression is largely restricted to the placenta during mouse embryogenesis. FBXL12 was found to interact specifically with members of the ALDH3 family and to mediate their polyubiquitylation. Finally, coimmunoprecipitation analysis revealed that FBXL12 interacted efficiently only with members of the ALDH3 family (ALDH3A1, ALDH3A2, and ALDH3B1), showing little if any association with those of the ALDH1 family (ALDH1A1, ALDH1A2, and ALDH1A3) (Fig. 2H). Collectively, these results suggested that SCFFBXL12 is an authentic E3 specific for ALDH3 family members.
Publications: 1 Organism: Mus Musculus
Tissue: Placenta
+ FBXL12down-regulates quantity by destabilization img/direct_inhibition.png binding ALDH3B1 0.321
Identifier Residue Sequence Organism Cell Line
SIGNOR-272815 Mus musculus
pmid sentence
We now show that SCFFBXL12 is an authentic E3 for the ALDH3 family of enzymes. We now show that the ubiquitin-dependent degradation of ALDH3 mediated by FBXL12 (F box and leucine-rich repeat protein 12) is essential for execution of the differentiation program of trophoblast stem cells (TSCs). FBXL12 is present only in eutherian mammals, and its expression is largely restricted to the placenta during mouse embryogenesis. FBXL12 was found to interact specifically with members of the ALDH3 family and to mediate their polyubiquitylation. Finally, coimmunoprecipitation analysis revealed that FBXL12 interacted efficiently only with members of the ALDH3 family (ALDH3A1, ALDH3A2, and ALDH3B1), showing little if any association with those of the ALDH1 family (ALDH1A1, ALDH1A2, and ALDH1A3) (Fig. 2H). Collectively, these results suggested that SCFFBXL12 is an authentic E3 specific for ALDH3 family members.
Publications: 1 Organism: Mus Musculus
Tissue: Placenta
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