Summary

Name GAR1
Full Name H/ACA ribonucleoprotein complex subunit 1
Synonyms Nucleolar protein family A member 1, snoRNP protein GAR1 | NOLA1
Primary ID Q9NY12
Links - -
Type protein
Relations 1
Function Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

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Relations

Regulator Mechanism target score ℹ
+ GAR1up-regulates activity img/direct-activation.png binding TERT 0.427
Publications: 1