4.0
Summary
| Name |  TERTView Modifications |
| Full Name | Telomerase reverse transcriptase |
| Synonyms | HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2 | EST2, TCS1, TRT |
| Primary ID | O14746 |
| Links |  -  -  |
| Type | protein |
| Relations | 25 |
| Pathways | GPCR_HCC, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA) |
| Function | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT1 | up-regulates 
phosphorylation
|
TERT | 0.734 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | AKT | up-regulates
phosphorylation
|
TERT | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA) | |||
| + | CDK1 | up-regulates activity
phosphorylation
|
TERT | 0.325 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | down-regulates 
phosphorylation
|
TERT | 0.417 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Av/b1 integrin | up-regulates quantity by expression 
|
TERT | 0.32 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NFX1 | up-regulates quantity by expression
transcriptional regulation
|
TERT | 0.523 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MKRN1 | down-regulates quantity by destabilization
polyubiquitination
|
TERT | 0.475 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | POT1 | up-regulates
binding
|
TERT | 0.674 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCA4 | up-regulates
binding
|
TERT | 0.778 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DKC1 | up-regulates activity
binding
|
TERT | 0.817 |
| Publications: | 1 | |||
| + | SIN3A | down-regulates quantity by repression 
transcriptional regulation
|
TERT | 0.306 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NHP2 | up-regulates activity
binding
|
TERT | 0.66 |
| Publications: | 1 | |||
| + | ACD | up-regulates
binding
|
TERT | 0.558 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MEN1 | down-regulates
|
TERT | 0.306 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | A6/b1 integrin | up-regulates quantity by expression
|
TERT | 0.307 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | DYRK2 | down-regulates activity
phosphorylation
|
TERT | 0.444 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TERT | up-regulates
|
Immortality | 0.7 |
| Publications: | 1 | |||
| Pathways: | Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA) | |||
| + | CTCF | down-regulates quantity by repression
transcriptional regulation
|
TERT | 0.329 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GAR1 | up-regulates activity
binding
|
TERT | 0.448 |
| Publications: | 1 | |||
| + | TERT | up-regulates
|
Telomere_maintenance | 0.7 |
| Publications: | 1 | |||
| + | NOP10 | up-regulates activity
binding
|
TERT | 0.624 |
| Publications: | 1 | |||
| + | NFX1 | up-regulates quantity by expression
transcriptional regulation
|
TERT | 0.523 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABL1 | down-regulates activity
phosphorylation
|
TERT | 0.662 |
| Publications: | 1 | Organism: | Homo Sapiens | |