Relation Results

Summary

Name DPP3
Full Name Dipeptidyl peptidase 3
Synonyms Dipeptidyl aminopeptidase III, Dipeptidyl arylamidase III, Dipeptidyl peptidase III, DPP III, Enkephalinase B |
Primary ID Q9NY33
Links - -
Type protein
Relations 2
Function Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-A ...
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Type: Score: Layout: SPV 
0.20.602DPP3Angiotensin-2KEAP1

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Relations
Regulator
Mechanism
target
score ℹ
+ DPP3down-regulates quantity by destabilization img/direct_inhibition.png cleavage Angiotensin-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268463 in vitro
pmid sentence
Human dipeptidyl-peptidase III (hDPP III) is capable of specifically cleaving dipeptides from the N-terminal of small peptides with biological activity such as angiotensin II (Ang II, DRVYIHPF), and participates in blood pressure regulation, pain modulation, and the development of cancers in human biological activities. The binding of Ang II to hDPP III may lead to changes in the shape and size of subsite S1, an important catalytic site, so as to promote the decomposition of the substrate.
Publications: 1 Organism: In Vitro
+ DPP3down-regulates quantity by destabilization img/direct_inhibition.png cleavage KEAP1 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-268464 Homo sapiens
pmid sentence
The influence of DPP3 on the Keap1-Nrf2/ARE signal pathway suggest a direct involvement of DPP3 in the oxidative stress response [8,14,31,53,99,100]. It was shown that DPP3 competes with Nrf2 through the ETGE motif to bind to Keap1 and consequently enhances the translocation of Nrf2 to the nucleus, thereby driving the expression of an array of genes encoding antioxidative enzymes [99]. More specifically, binding of DPP3 to Keap1 releases Nrf2, and thus, prevents its degradation through the 26S proteasome
Publications: 1 Organism: Homo Sapiens
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