| Name
|
 TERF2IP
|
| Full Name |
Telomeric repeat-binding factor 2-interacting protein 1 |
| Synonyms |
TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1 | DRIP5, RAP1 |
| Primary ID |
Q9NYB0 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly |
3.0
binding