| + |
Shelterin complex | down-regulates activity 
binding
|
ATM |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263322 |
|
|
|
|
| pmid |
sentence |
| 18680434 |
It is not yet clear how the presence of TRF2 at telomeres averts the activation of the ATM kinase.> In this regard, overexpression of TRF2can dampen the activation of the ATM kinase, even at nontelomeric sites of DNA damage (95). Furthermore, TRF2 can interact with the ATM kinase as well as with the Mre11 complex |
|
| Publications: |
1 |
| + |
TINF2 | form complex 
binding
|
Shelterin complex |
0.887 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263320 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15383534 |
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins|Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Shelterin complex | up-regulates 
|
Telomere_maintenance |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263309 |
|
|
|
|
| pmid |
sentence |
| 33015044 |
The shelterin complex has six proteins, containing TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. The shelterin complex is localized to the chromosome end and protects telomeric DNA (Palm and de Lange, 2008). The TTM complex acts as a “linker” and bridges the LINC and shelterin complexes together. The connection between TTM and shelterin complexes is well-known, which is mediated by TERB1 and TRF1 |
|
| Publications: |
1 |
| + |
TERF2IP | form complex
binding
|
Shelterin complex |
0.833 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263319 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15383534 |
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins|Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TERF1 | form complex
binding
|
Shelterin complex |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263316 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15383534 |
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins|Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTM complex | up-regulates activity 
relocalization
|
Shelterin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263308 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33015044 |
The shelterin complex has six proteins, containing TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. The shelterin complex is localized to the chromosome end and protects telomeric DNA (Palm and de Lange, 2008). The TTM complex acts as a “linker” and bridges the LINC and shelterin complexes together. The connection between TTM and shelterin complexes is well-known, which is mediated by TERB1 and TRF1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POT1/ACD | form complex
binding
|
Shelterin complex |
0.861 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263318 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15383534 |
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins|Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TERF2 | form complex
binding
|
Shelterin complex |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263317 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15383534 |
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins|Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Shelterin complex
CPX-152