Summary

Name PSENEN
Full Name Gamma-secretase subunit PEN-2
Synonyms Presenilin enhancer protein 2 | PEN2
Primary ID Q9NZ42
Links - -
Type protein
Relations 5
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

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Relations

Regulator Mechanism target score ℹ
+ PSENENup-regulates img/direct-activation.png cleavage RYK 0.2
Publications: 1 Organism: Homo Sapiens
+ PSENENup-regulates img/direct-activation.png cleavage PSEN1 0.959
Publications: 1 Organism: Homo Sapiens
+ APH1Bup-regulates img/direct-activation.png binding PSENEN 0.94
Publications: 1 Organism: Homo Sapiens
+ APH1Aup-regulates img/direct-activation.png binding PSENEN 0.962
Publications: 1 Organism: Homo Sapiens
+ PSENENform complex img/form-complex.png binding gamma-secretase 0.96
Publications: 1 Organism: Homo Sapiens