| + |
WNT1 | up-regulates 
binding
|
RYK |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Mammalian ryk is a wnt coreceptor required for stimulation of neurite outgrowth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates
binding
|
RYK |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Here, we report that ryk directly binds wnt-1 and wnt-3a via its wif domain and is required for the tcf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates
binding
|
RYK |
0.776 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22773843 |
Purified human RYK binds to mouse Wnt1, 3a and 5a expressed in HEK293 cells. Separate experiments show that human RYK also immunopreciptitates human VANGL2 when the proteins are co-expressed in HEK293 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RYK | up-regulates
binding
|
FZD8 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150010 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17035295 |
Interaction between ryk and fz has been reported, suggesting that the two proteins may form a multi-receptor complex signalling through the canonical pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | down-regulates 
ubiquitination
|
RYK |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176282 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21875946 |
We discovered that ryk both physically and functionally interacts with the e3 ubiquitin ligase mind bomb 1 (mib1).We Found that overexpressed ryk and mib1 colocalized and that the overexpression of mib1 leads to the loss of surface ryk expression. In addition, biochemical studies revealed that mib1 promotes the ubiquitination and degradation of ryk. Endogenous ryk and mib1 were required for the wnt-dependent activation of wnt/ctnnb1 signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RYK | up-regulates
binding
|
DVL3 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RYK | up-regulates
binding
|
DVL1 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RYK | up-regulates
binding
|
DVL2 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PSENEN | up-regulates
cleavage
|
RYK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182145 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19000841 |
Ryk activity is modulated through cleavage of its icd by gamma-secretase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RYK
- 
- 