Summary

Name C9orf78
Full Name Splicing factor C9orf78
Synonyms Hepatocellular carcinoma-associated antigen 59 | HCA59
Primary ID Q9NZ63
Links - -
Type protein
Relations 1
Function Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}.

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Relations

Regulator Mechanism target score ℹ
+ SMURF1 img/unknown.png ubiquitination C9orf78 0.2
Publications: 1 Organism: In Vitro