3.0
Summary
| Name |  EHF
|
| Full Name | ETS homologous factor |
| Synonyms | hEHF, ETS domain-containing transcription factor, Epithelium-specific Ets transcription factor 3, ESE-3 | ESE3, ESE3B, ESEJ |
| Primary ID | Q9NZC4 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. |
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transcriptional regulation
transcriptional regulation