3.0
Summary
| Name |  NDUFA13
|
| Full Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
| Synonyms | Cell death regulatory protein GRIM-19, Complex I-B16.6, CI-B16.6, Gene associated with retinoic and interferon-induced mortality 19 protein, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B16.6 subunit | GRIM19 |
| Primary ID | Q9P0J0 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NDUFA13 | form complex 
binding
|
Mitochondrial respiratory chain complex I | 0.779 |
| Publications: | 1 | |||