Relation Results

Summary

Name POLR1H
Full Name DNA-directed RNA polymerase I subunit RPA12
Synonyms Zinc ribbon domain-containing protein 1 | RPA12
Primary ID Q9P1U0
Links - -
Type protein
Relations 3
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p ...
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Type: Score: Layout: SPV 
0.20.20.2POLR1HBCL2RNA Polymerase IABCB1

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Relations
Regulator
Mechanism
target
score ℹ
+ POLR1Hup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259908 Homo sapiens
pmid sentence
ZNRD1 could significantly up-regulate the expression of P-gp, Bcl-2, and the transcription of the MDR1 gene but not alter the expression of MDR-associated protein, glutathione S-transferase activity, or intracellular glutathione content in leukemia cells.
Publications: 1 Organism: Homo Sapiens
+ POLR1Hform complex img/form-complex.png binding RNA Polymerase I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266156
pmid sentence
In eukaryotic cells, the RNA polymerase Pol I synthesizes the rRNA precursor, Pol II transcribes mRNAs and small non-coding RNAs (such as small nuclear RNAs), and Pol III produces tRNAs and other small RNAs. Pol I, II and II contain 14, 12 and 17 polypeptide subunits, respectively (Table 1). 
Publications: 1
+ POLR1Hup-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259907 Homo sapiens
pmid sentence
ZNRD1 could significantly up-regulate the expression of P-gp, Bcl-2, and the transcription of the MDR1 gene but not alter the expression of MDR-associated protein, glutathione S-transferase activity, or intracellular glutathione content in leukemia cells.
Publications: 1 Organism: Homo Sapiens
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