| + |
FNIP2 | down-regulates activity 
binding
|
HSP90AA1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261414 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27353360 |
FNIP1 and FNIP2 facilitate FLCN binding to Hsp90 chaperone. Our results suggest that FNIP1 is a potent inhibitor of Hsp90 ATPase activity, as 200 nM of FNIP1 inhibits Hsp90 ATPase activity by 50-fold. FNIP2 also has shown inhibitory activity towards Hsp90; however, it required 1.6 μM of FNIP2 to inhibit the ATPase activity by eightfold. Although we use the term ‘inhibition' here, FNIPs seem only to be slowing the chaperone cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FNIP2 | down-regulates activity
binding
|
HSP90AB1 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261416 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27353360 |
FNIP1 and FNIP2 facilitate FLCN binding to Hsp90 chaperone. Our results suggest that FNIP1 is a potent inhibitor of Hsp90 ATPase activity, as 200 nM of FNIP1 inhibits Hsp90 ATPase activity by 50-fold. FNIP2 also has shown inhibitory activity towards Hsp90; however, it required 1.6 μM of FNIP2 to inhibit the ATPase activity by eightfold. Although we use the term ‘inhibition' here, FNIPs seem only to be slowing the chaperone cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FNIP2
- 
- 