| + |
CTTNBP2NL | up-regulates activity 
binding
|
STRN4 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261701 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23015759 |
Although CTTNBP2 and CTTNBP2NL are different in terms of tissue and subcellular distribution, our data indicate that, similar to CTTNBP2NL, CTTNBP2 associates with members of the striatin family, namely striatin and zinedin. Moreover, CTTNBP2 is critical for the distribution of striatin and zinedin in dendritic spines. The role of CTTNBP2 in the regulation of the synaptic distribution of striatin and zinedin suggests that CTTNBP2 regulates synaptic signaling through PP2A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTNBP2NL | up-regulates activity
binding
|
CTTN |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261695 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23015759 |
CTTNBP2NL interacts with cortactin and targets cortactin to stress fibers. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CTTNBP2NL | up-regulates activity
binding
|
STRN |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23015759 |
Although CTTNBP2 and CTTNBP2NL are different in terms of tissue and subcellular distribution, our data indicate that, similar to CTTNBP2NL, CTTNBP2 associates with members of the striatin family, namely striatin and zinedin. Moreover, CTTNBP2 is critical for the distribution of striatin and zinedin in dendritic spines. The role of CTTNBP2 in the regulation of the synaptic distribution of striatin and zinedin suggests that CTTNBP2 regulates synaptic signaling through PP2A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTNBP2NL | up-regulates 
|
Actin_cytoskeleton_reorganization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261694 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23015759 |
Through alternative splicing, a single CTTNBP2 gene encodes three different transcripts, namely short (S), long (L), and intron forms. The interaction with cortactin is required for the function of CTTNBP2-S in dendritic spine formation because the CTTNBP2-S mutant, which no longer interacts with cortactin, is unable to rescue the spine defects resulting from CTTNBP2 knockdown. Thus CTTNBP2-S may control cortactin–F-actin cytoskeletons and regulate the formation and maintenance of dendritic spines in neurons. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
CTTNBP2NL
- 
- 