Summary

Name MARCHF4
Full Name E3 ubiquitin-protein ligase MARCHF4
Synonyms Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, RING-type E3 ubiquitin transferase MARCH4 | KIAA1399, RNF174
Primary ID Q9P2E8
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination MARCHF4 0.2
Publications: 1 Organism: Homo Sapiens