3.0
Summary
| Name |  MARCHF4
|
| Full Name | E3 ubiquitin-protein ligase MARCHF4 |
| Synonyms | Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, RING-type E3 ubiquitin transferase MARCH4 | KIAA1399, RNF174 |
| Primary ID | Q9P2E8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
ubiquitination