4.0
Summary
| Name |  LARS1View Modifications |
| Full Name | Leucine--tRNA ligase, cytoplasmic |
| Synonyms | Leucyl-tRNA synthetase, LeuRS | KIAA1352, LARS |
| Primary ID | Q9P2J5 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LRRK2 | down-regulates activity 
phosphorylation
|
LARS1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | LARS1 | form complex 
binding
|
Multiaminoacyl-tRNA synthetase | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATF4 | up-regulates quantity by expression 
transcriptional regulation
|
LARS1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |