Relation Results

Summary

Name PDP2
Full Name [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Synonyms PDP 2, Pyruvate dehydrogenase phosphatase catalytic subunit 2, PDPC 2 | KIAA1348
Primary ID Q9P2J9
Links - -
Type protein
Relations 2
Function Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

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Type: Score: Layout: SPV 
0.2440.644PDP2SMAD1PDHA1

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Relations
Regulator
Mechanism
target
score ℹ
+ PDP2down-regulates img/direct_inhibition.png dephosphorylation SMAD1 0.244
Identifier Residue Sequence Organism Cell Line
SIGNOR-144909 Homo sapiens
pmid sentence
We show that the mammalian pdps are important in dephosphorylation of bmp-activated smad1 but not tgf-beta-activated smad2 or smad3. Thus, pdps specifically inactivate smads in the bmp/dpp pathway. [...] These observations suggest that pdp1 and pdp2 are important for dephosphorylation of smad1.
Publications: 1 Organism: Homo Sapiens
+ PDP2up-regulates activity img/direct-activation.png dephosphorylation PDHA1 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-251665 Homo sapiens
pmid sentence
Pyruvate dehydrogenase phosphatase (PDP) is a mitochondrial serine phosphatase that activates phosphorylated pyruvate dehydrogenase complex by dephosphorylation
Publications: 1 Organism: Homo Sapiens
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