Relation Results

Summary

Name ARHGAP28
Full Name Rho GTPase-activating protein 28
Synonyms Rho-type GTPase-activating protein 28 | KIAA1314
Primary ID Q9P2N2
Links - -
Type protein
Relations 1
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

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Type: Score: Layout: SPV 
0.483ARHGAP28RHOA

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Relations
Regulator
Mechanism
target
score ℹ
+ ARHGAP28down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.483
Identifier Residue Sequence Organism Cell Line
SIGNOR-260483 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
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