| + |
hsa-miR-92a-3p | down-regulates quantity by repression 
post transcriptional regulation
|
DKK3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278833 |
|
|
Homo sapiens |
SH-SY5Y Cell |
| pmid |
sentence |
| 21572098 |
We also documented that the MYCN-regulated miRNAs, miR-92a, mir-92b, efficiently decreased expression of a luciferase reporter containing the 3'UTR sequence from DKK3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-92b-5p | down-regulates quantity by repression
post transcriptional regulation
|
DKK3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278834 |
|
|
Homo sapiens |
SH-SY5Y Cell |
| pmid |
sentence |
| 21572098 |
We also documented that the MYCN-regulated miRNAs, miR-92a, mir-92b, efficiently decreased expression of a luciferase reporter containing the 3'UTR sequence from DKK3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-183-5p | down-regulates quantity by repression
post transcriptional regulation
|
DKK3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278016 |
|
|
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 23538390 |
This is the first report to show that the oncogenic miR-183 activates the Wnt/b-catenin pathway by directly inhibiting tumour suppressors Dkk-3 and SMAD4 in PC.| indicating that Dkk-3 and SMAD4 are direct targets of miR-183. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-582-3p | down-regulates quantity by repression
post transcriptional regulation
|
DKK3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278018 |
|
|
Homo sapiens |
NCI-H1703 Cell |
| pmid |
sentence |
| 26468775 |
MiR-582-3p directly targets multiple negative regulators of the Wnt pathway. | Overall, our results demonstrate that miR-582-3p activates Wnt signalling by targeting AXIN2, DKK3 and SFRP1 enhances stem cell-like traits; and leads to tumour recurrence and poor prognosis in NSCLC patients. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRX1 | down-regulates quantity by repression 
transcriptional regulation
|
DKK3 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261658 |
|
|
Homo sapiens |
SGC-7901 Cell |
| pmid |
sentence |
| 20440264 |
We identified a number of target genes by global microarray analysis after IRX1 transfection combined with real-time PCR and chromatin immunoprecipitation assay.| Downregulation of BDKRB2, PHYHIPL, HIST2H2BE, FGF7, PTGER1, NPTX1, EGR1, COL9A3, CUGBP2, DKK3 and BPI was confirmed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DKK3
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