Relation Results

Summary

Name FAM8A1
Full Name Protein FAM8A1
Synonyms Autosomal highly conserved protein | AHCP
Primary ID Q9UBU6
Links - -
Type protein
Relations 1
Function Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD) ...
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Type: Score: Layout: SPV 
0.581FAM8A1SYVN1

Relations

Regulator
Mechanism
target
score
+ up-regulates activity img/direct-activation.png binding SYVN1 0.581
Identifier Residue Sequence Organism Cell Line
SIGNOR-261348 Homo sapiens HEK-293 Cell
pmid sentence
FAM8A1 enhances binding of Herp to Hrd1, an interaction that is required for ERAD. Our findings support a model of Hrd1 complex formation, where the Hrd1 cytoplasmic domain and FAM8A1 have a central role in the assembly and activity of this ERAD machinery. A conserved Hrd1 cytoplasmic domain interacts with FAM8A1 and Herp
Publications: 1 Organism: Homo Sapiens
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