TCF-20, Nuclear factor SPBP, Protein AR1, Stromelysin-1 PDGF-responsive element-binding protein, SPRE-binding protein | KIAA0292, SPBP
Primary ID
Q9UGU0
Links
- -
Type
protein
Relations
1
Function
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
This result indicates that expression of SPBP is sufficient to transactivate a minimal promoter containing a single copy of the SPRE, as well as the full-length stromelysin promoter.