3.0
Summary
| Name |  NPC1L1
|
| Full Name | NPC1-like intracellular cholesterol transporter 1 |
| Synonyms | NPCL1_HUMAN | |
| Primary ID | Q9UHC9 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
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transcriptional regulation